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Lymphoid tissue regeneration

Lab Leader: Jonathan Tan
Overview

The Lymphoid Tissue Regeneration Lab focuses on the spleen as a secondary lymphoid organ which possesses the unique capacity to naturally regenerate, and to support extramedullary hematopoiesis.

 

Our research involves the use of spleen tissue grafting and regeneration models, isolating and transplanting hematopoietic stem cells (HSC), single cell sorting, and transcriptome profiling.

 

The goals of this research are to dissect the cellular components driving spleen tissue development and regeneration, and to understand the role of spleen HSC in steady-state hematopoiesis and myeloid cell production.

Overview
Research Areas
Members
Lab Leader:

Dr Jonathan Tan

.

Research Fellow

Clem Jones Centre for Regenerative Medicine

Researchers:

Ms Karin Tourle

.

Senior Research Assistant

Centre Research Manager

Students:

Ms Christie Short

.

PhD Candidate

Amber Rucinski

.

MD Student

Alexandar Grainger

.

MD Student

Past Students:

Ms Jacqualine Kaden

.

Masters

Jae Sung Lim

.

MD Project

Sibi Narayanan

.

MD Project

Collaborators:

Professor Helen O'Neill

.

Bond University, Australia

A/Prof Mike Doran

.

QUT, Australia

Dr Katie Powell

.

Bond University, Australia

Professor Takeshi Watanabe

.

Kyoto University, Japan

A/Prof Joseph Powell

.

Garvan Institute, Australia

Dr Jason Limnios

.

Bond University, Australia

Members
Featured Publications

- Tan, J. and Watanabe, T. (2018) Determinants of postnatal spleen tissue regeneration and organogenesis. npj Regenerative Medicine. 3:1

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- Golub, R., Tan J., Watanabe, T., Brendolan A. (2018) Origin and Immunological Functions of Spleen Stromal Cells. Trends in Immunology. In Press

 

- Tan, J. and Watanabe, T. (2017) Stromal cell subsets directing neonatal spleen regeneration. Scientific Reports. 7:40401

 

- Tan, J. and Watanabe, T. (2014) Murine spleen tissue regeneration from neonatal spleen capsule requires lymphotoxin priming of stromal cells. Journal of Immunology. 193:1194-203

 

- Tan, J. and Watanabe, T. (2010) Artificial engineering of secondary lymphoid organs. Advances in Immunology. 105:131-57

 

- Tan, J., Periasamy, P., O’Neill, H.C. (2010) Delineation of precursors in murine spleen that develop in contact with splenic endothelium to give novel dendritic-like cells. Blood. 115(18):3678-85

 

- Tan, J. and O’Neill, H.C. (2005) Maturation requirements for dendritic cells in T cell stimulation leading to tolerance versus immunity. Journal of Leukocyte Biology. 78(2): 319-24

Funding

Developmental ELN Grant

$5,360 - Tourle, 2018-2022

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Bond University Vice-Chancellor’s Research Seed Grant

$10,000 - Tan, 2016

“The hematopoietic potential of stem cells in spleen”

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NHMRC New Investigator Project Grant

$401,398 - Tan, 2015-2018

“Understanding the mechanisms that regulate spleen organogenesis”

 

NHMRC CJ Martin Postdoctoral Fellow

$331,620 - Tan, 2011-2015

“Understanding spleen cellular development and synthesis of artificial tissue”

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Japan Society for Promotion of Science (JSPS) Postdoctoral Fellow

$94,000 - Tan, 2009-2011

Publications
Funding
Media

Synthetic organogenesis of an artificial spleen. (2013) International Innovation. Jan:73-5

Media
CONTACT
Need more details? Contact us

We are currently accepting PhD students.

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