Overview
The Lymphoid Tissue Regeneration Lab focuses on the spleen as a secondary lymphoid organ which possesses the unique capacity to naturally regenerate, and to support extramedullary hematopoiesis.
Our research involves the use of spleen tissue grafting and regeneration models, isolating and transplanting hematopoietic stem cells (HSC), single cell sorting, and transcriptome profiling.
The goals of this research are to dissect the cellular components driving spleen tissue development and regeneration, and to understand the role of spleen HSC in steady-state hematopoiesis and myeloid cell production.
Members
Researchers:
Ms Karin Tourle
.
Senior Research Assistant
Centre Research Manager
Students:
Ms Christie Short
.
PhD Candidate
Amber Rucinski
.
MD Student
Alexandar Grainger
.
MD Student
Past Students:
Ms Jacqualine Kaden
.
Masters
Jae Sung Lim
.
MD Project
Sibi Narayanan
.
MD Project
Collaborators:
Professor Helen O'Neill
.
Bond University, Australia
A/Prof Mike Doran
.
QUT, Australia
Dr Katie Powell
.
Bond University, Australia
Professor Takeshi Watanabe
.
Kyoto University, Japan
A/Prof Joseph Powell
.
Garvan Institute, Australia
Dr Jason Limnios
.
Bond University, Australia
Featured Publications
- Tan, J. and Watanabe, T. (2018) Determinants of postnatal spleen tissue regeneration and organogenesis. npj Regenerative Medicine. 3:1
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- Golub, R., Tan J., Watanabe, T., Brendolan A. (2018) Origin and Immunological Functions of Spleen Stromal Cells. Trends in Immunology. In Press
- Tan, J. and Watanabe, T. (2017) Stromal cell subsets directing neonatal spleen regeneration. Scientific Reports. 7:40401
- Tan, J. and Watanabe, T. (2014) Murine spleen tissue regeneration from neonatal spleen capsule requires lymphotoxin priming of stromal cells. Journal of Immunology. 193:1194-203
- Tan, J. and Watanabe, T. (2010) Artificial engineering of secondary lymphoid organs. Advances in Immunology. 105:131-57
- Tan, J., Periasamy, P., O’Neill, H.C. (2010) Delineation of precursors in murine spleen that develop in contact with splenic endothelium to give novel dendritic-like cells. Blood. 115(18):3678-85
- Tan, J. and O’Neill, H.C. (2005) Maturation requirements for dendritic cells in T cell stimulation leading to tolerance versus immunity. Journal of Leukocyte Biology. 78(2): 319-24
Funding
Developmental ELN Grant
$5,360 - Tourle, 2018-2022
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Bond University Vice-Chancellor’s Research Seed Grant
$10,000 - Tan, 2016
“The hematopoietic potential of stem cells in spleen”
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NHMRC New Investigator Project Grant
$401,398 - Tan, 2015-2018
“Understanding the mechanisms that regulate spleen organogenesis”
NHMRC CJ Martin Postdoctoral Fellow
$331,620 - Tan, 2011-2015
“Understanding spleen cellular development and synthesis of artificial tissue”
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Japan Society for Promotion of Science (JSPS) Postdoctoral Fellow
$94,000 - Tan, 2009-2011
Media
Synthetic organogenesis of an artificial spleen. (2013) International Innovation. Jan:73-5