Stromal organiser cells in spleen
The capacity for spleen to naturally regenerate has been recognised for decades. However, the exact cells which control tissue regeneration have remained elusive. Using murine models, we have recently identified stromal “organiser” cells which are essential for spleen tissue regeneration. Our research looks at characterising the basic identity of this cell type, and asking whether it partners with other cells to control tissue organisation.
The overall goals of this research are to define the minimal cellular requirements for graft construction, and to investigate alternative therapies for enhancing spleen tissue function. In the long-term, we anticipate this will translate into efficient transplant options for asplenic individuals, and the opportunity to reverse declining immune function that is associated with ageing.
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Researchers: Jonathan Tan, Karin Tourle